Pharmaceutical compostion containing meltrin antagonist

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/00 (2006.01) A61K 31/4725 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07K 16/18 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2576093

Mainly concerning the pharmaceutical field, it is intended to exert an inhibitory effect on the function of meltrin .alpha. of promoting the differentiation of adipocytes by preparing a compound serving as an antagonist to meltrin .alpha. (for example, an antisense inhibiting the expression of a meltrin .alpha. gene or an anti-meltrin .alpha. antibody capable of inhibiting the physiological activity of meltrin .alpha.) and administering the same. By employing such a meltrin .alpha. antagonist as described above as the active ingredient, it becomes possible to provide a preventive/remedy which is efficacious against fatness, obesity or various diseases caused by obesity or relating thereto such as diabetes.

L'invention, concernant principalement le domaine pharmaceutique, consiste à exercer un effet inhibiteur du fonctionnement de la meltrine a consistant à promouvoir la différenciation des adipocytes, en préparant un composé servant d'antagoniste vis-à-vis de la meltrine a (par exemple un antisens inhibant l'expression d'un gène de la meltrine a ou un anticorps anti-meltrine a capable d'inhiber l'activité physiologique de la meltrine a) et en administrant celui-ci. En employant un antagoniste de la meltrine a tel que décrit ci-dessus comme ingrédient actif, il devient possible de produire un agent préventif/un remède lequel est efficace contre l'embonpoint, l'obésité ou différentes maladies provoquées par l'obésité ou liées à celle-ci telles que le diabète.

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