Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2081133

ABSTRACT A compound having pharmaceutical activity, of the formula Image (I) in which A is hydrogen or Image where x is 0 or 1 to 4, R1 and R2 are each hydrogen or C1-9 alkyl and R3 is -CN, -COOH, tetrazolyl or Image where R4 is optionally substituted phenyl, and -?-Y-Z- is selected from Image , Image , Image , Image and -?-N=N- where R5 and R6 are each hydrogen, C1-9 alkyl or Image where x, R1, R2 and R3 are as defined above, and R7 is hydrogen, C1-4 alkyl or Image where x is 1 to 4, and R1, R2 and R3 are as defined above; provided that when A is hydrogen at least one of R5, R6 and R7 is Image , and provided that when -?-Y-Z- is Image , A is Image and x is 1 to 4 then R3 is Image ; and salts and esters thereof. G.1274 FF

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