Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

167/234, 260/301

C07D 285/08 (2006.01) A61K 31/425 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2039955

PHARMACEUTICAL COMPOUNDS ABSTRACT OF THE INVENTION Pharmaceutical compounds of the following formula are described: Image (I) in which R1 is hydrogen, C1-4 alkyl, C1-4 alkoxy C1-4 alkyl, hydroxy-C1-4 alkyl, optionally substituted phenyl, optionally substituted phenyl-C1-4 alkyl or a heterocycle selected from: Image where R3 is hydrogen, C1-4 alkyl, C1-4 alkoxy, nitro, halo, cyano, trifluoromethyl, carboxyl or -CONnH2, and R4 is C1-4 alkyl; and R is hydrogen, C1-4 alkyl, phenyl or thienyl substituted with a carboxyl or C1-4 alkoxy-carbonyl group, an acyl group of the formula R5Co- where R5 is hydrogen, C1-4 alkyl, C1-4 alkoxy-C1-4 alkyl, halo C1-4 alkyl, C1-4 alkoxy, halo-C1-4 alkoxy, phenyl, phenyl-C1-4 alkyl, -NHC1-4 alkyl, -NH phenyl or Image where R6 is C1-4 alkyl, or a group of the formula -CH=C(COC1-4 alkoxy)2; or a salt thereof.

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