Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 311/92 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2079428

PHARMACEUTICAL COMPOUNDS ABSTRACT OF THE INVENTION A pharmaceutical compound of the formula Image (I) in which n is 0, 1 or 2 and R1 is attached at any of the positions 5, 6, 7, 8, 9 or 10, and each R1 is halo, trifluoromethyl, C1-4 alkoxy, hydroxy, nitro, C1-4 alkyl, C1-4 alkylthio, hydroxy-C1-4 alkyl, hydroxy-C1-4 alkoxy,trifluoromethoxy, carboxy, -COOR5 where R5 is an ester group, -CONR6R7 or -NR6R7 where R6 and R7 are each hydrogen or C1-4 alkyl; R2 is phenyl, naphthyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl, naphthyl and heteroaryl groups being optionally substituted, or R2 is furanyl optionally substituted with C1-4 alkyl; R3 is nitrile, carboxy, -COOR8 where R8 is an ester group, -CONR9R10 where R9 and R10 are each hydrogen or C1-4 alkyl, or R11SO2- where R11 is C1-4 alkyl or optionally substituted phenyl; and R4 is -NR12R13, -NHCOR12, -N(COR12)2 or -N=CHOCH2R12 where R12 and R13 are each hydrogen or C1-4 alkyl optionally substituted with carboxy, Image where X is C2-4 alkylene, or -NHSO2R14 where R14 is C1-4 alkyl or optionally substituted phenyl; provided that when n is 0, R3 is nitrile and R4 is -NH2, R2 is not phenyl or phenyl substituted in the para-position with a single chloro, hydroxy or methoxy substituent; and salts thereof. CMH/VAG/1307/92

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