Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

167/207, 260/263

C07D 239/42 (2006.01) C07D 207/34 (2006.01) C07D 277/46 (2006.01) C07D 307/66 (2006.01) C07D 333/36 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1290335

NOVEL PHARMACEUTICAL COMPOUNDS ABSTRACT OF THE INVENTION Compounds of the following formula have pharmaceutical properties: Image in which X is R'(HO)C=C(CN)-, R1(CO)-CH(CN)- or Image R1 and R2 are each hydrogen or C1-6 alkyl, R3, R4, R5 and R6 are each hydrogen, hydroxy, halogen, nitro, cyano, carboxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, halo-substituted C1-4 alkyl, halo-substituted C1-4 alkoxy, halo-substituted C1-4 alkylthio, C2-5 alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, R'R"N- where R' and R" are each hydrogen or C1-4 alkyl or R''' CONH- where R''' is C1-4 alkyl, or a group of the formula -CR7R8R9 in which R7, R8 and R9 are each C1-6 alkyl, halo-substituted C1-6 alkyl or optionally substituted phenyl, or R7 and R8, together with the carbon atom to which they are attached, form a cycloalkyl group containing 3 to 7 carbon atoms, or R7, R8 and R9 together with the carbon atom to which they are attached, form a bicycloalkyl group containing 4 to 9 carbon atoms, and Y is a 5- or 6-membered heterocyclic ring excluding pyrazole; and salts thereof.

543738

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