Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

C

C07C 229/30 (2006.01) A61K 31/195 (2006.01) A61K 31/275 (2006.01) C07C 229/32 (2006.01) C07C 229/36 (2006.01) C07C 229/44 (2006.01) C07C 255/58 (2006.01) C07C 323/63 (2006.01)

Patent

CA 2233077

A pharmaceutical compound of the formula: Image in which n is 1 or 2, R1 is -CO2H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-4 alkyl, optionally substituted phenyl C2-10 alkenyl,(optionally substituted phenyl)2-C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C3-7 cycloalkyl-C1-4 alkyl or optionally substituted C3-7 cycloalkyl-C2-10 alkenyl, or R2 and R3, together with the carbon atom to which they are attached, form an optionally substituted C4-7 cycloalkyl group; or a salt or ester thereof other than the compounds .gamma.-propylidene -L- glutamic acid, .gamma.-ethylidene-L-glutamic acid and .gamma.-methylidene -L- glutamic acid.

Composé pharmaceutique de formule Image , dans laquelle n est 1 ou 2, R1 est -CO2H, R2 est de l'hydrogène ou un alkyle C1-4, et R3 est de l'hydrogène, un groupe alkyle C1-10, alcényle C2-10, phényle avec substitution facultative, phénylalkyle C1-4 avec substitution facultative, phénylalcényle C2-10 avec substitution facultative, (phényle avec substitution facultative)2-alkyle C1-4, cycloalkyle C3-7 avec substitution facultative, cycloalkyle C3-7-alkyle C1-4 avec substitution facultative, ou cycloalkyle C3-7-alcényle C2-10 avec substitution facultative, ou alors R2 et R3 forment ensemble avec l'atome de carbone auquel ils sont liés un cycloalkyle C4-7 avec substitution facultative; ou un de ses sels ou esters, autre que les composés acide gamma-propylidène-L-glutamique, acide gamma-éthylidène-L-glutamique et acide gamma-méthylidène-L-glutamique.

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