Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2157998

A pharmaceutical compound of the formula Image (I) in which R1 and R7 are each halo, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R2 and R3 are each hydrogen or C1-6 alkyl, R4 and R5 are each hydrogen, halo, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R6 is hydrogen, C1-6 alkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heteroaryl, optionally substituted phenyl-C1-6 alkyl or -CO2R8 where R8 is an ester group, m and p are each 0, 1, 2, 3 or 4, n is 1, 2, 3 or 4, Z is Image , ?O? , ?S? or Image where R9 and R10 are each hydrogen, C1-6 alkyl or optionally substituted phenyl-C1-6 alkyl, X is oxygen or sulphur, and Y is Image or Image where R11 and R12 are each hydrogen, C1-6 alkyl, trifluoromethyl, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl; and salts and solvates thereof.

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