C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2650290
Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Les composés de Formule Ia et Ib, ainsi que les stéréoisomères, isomères géométriques, tautomères, solvates, métabolites et sels de qualité pharmaceutique desdits composés peuvent être employés dans l'inhibition des lipides kinases, y compris PI3K, et dans le traitement de troubles les faisant intervenir, tels que le cancer. La présente invention a également pour objet des méthodes d'utilisation des composés de Formule Ia et Ib dans des diagnosticsin vitro, in situ et in vivo, ainsi que dans le traitement prophylactique ou thérapeutique de tels troubles dans les cellules de mammifères, ou d'états pathologiques associés.
Castanedo Georgette
Chuckowree Irina
Folkes Adrian
Goldsmith Richard
Gunzner Janet
F. Hoffmann-La Roche Ag
Genentech Inc.
Smart & Biggar
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