Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 333/70 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2082839

ABSTRACT Compounds of the formula: Image in which each R1 is hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen or nitro, and n is 0, 1, 2 or 3, R2 is hydrogen, C1-4 alkyl or C2-4 alkenyl, R3 and R4 are each hydrogen, C1-4 alkyl, optionally substituted phenyl or C6-9 cycloalkyl optionally substituted by 1 to 4 C1-4 alkyl groups, R5 is optionally substituted phenyl, tetrahydronaphthyl, phthalimido, saccharinyl, glutaramido, C6-10 cycloalkyl optionally substituted with 1 to 4 C1-4 alkyl groups or a phenyl group, or C4-9 heterosubstituted cycloalkyl optionally substituted with 1 to 4 alkyl groups, x is 1, 2 or 3, y is 0 or 1 and z is 0, 1, 2 or 3; and salts thereof. The compounds are indicated for use in the treatment of disorders of the central nervous system. G.1275 FF

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