Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 311/92 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 407/04 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2089974

ABSTRACT Pharmaceutical compounds of the formula Image in which n is 0, 1 or 2 and R1 is attached at any of the positions 7, 8, 9 or 10, and each R1 is halo, carboxy, triluoromethyl, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, hydroxy-C1-4 alkyl, hydroxy-C1-4 alkoxy, nitrogen-containing heterocyclyl, nitro, trifluoromethoxy, -COOR5 where R5 is an ester group, -COR6, -CONR6R7 or -NR6R7 where R6 and R7 are each hydrogen or C1-4 alkyl; R2 is phenyl, naphthyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl, naphthyl and heteroaryl groups being optionally substituted, or R2 is furanyl optionally substituted with C1-4 alkyl; R3 is nitrile, carboxy, -COOR8 where R8 is an ester group, or -CONR9R10 where R9 and R10 are each hydrogen or C1-4 alkyl and R4 is -NR11R12, -NR11COR12, -N(COR11)2 or -N=CHOCH2R11 where R11 and R12 are each hydrogen or C1-4 alkyl optionally substltuted with carboxy, -N=CH-NR13R14 where R13 is hydrogen or C1-4 alkyl and R14 is C1-4 alkyl, optionally substituted phenyl or optionally substituted heteroaryl, Image where X is C2-4 alkylene, or -NHSO2R15 where R15 is C1-4 alkyl, trifluoromethyl or optionally substituted phenyl; and salts thereof. G.1277 FF

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