Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 265/02 (2006.01) A61K 31/535 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2349482

Use of a compound of formula (I) in which, R1, R2 and R3 are independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C10)cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl(C1-C6)alkyl, unsubstituted or substituted aryl(c2-C6)alkenyl, halo, carboxy, (C1-C6)alkoxycarbonyl or - (CH2)m-OH wherein m is 1, 2 or 3; --- indicates a single or a double bond; X and Y are each independently hydrogen, or X and Y together represent a bridge of the formula -(CH2)n-, where n is 1 or 2; A1 and A2 are each independently an unsubstituted or substituted aryl; Z is -CO-, -SO2- or -CH2-; provided that, when Z is -CO-, A1 is not 3,4,5-trimethoxyphenyl; or a pharmaceutically- acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a condition indicating the administration of a selective mGluR1 antagonist.

L'invention concerne l'utilisation d'un composé de formule (I) répondant à la définition du descriptif, ou d'un sel ou d'un ester pharmaceutiquement acceptables de ce composé, pour la préparation d'un médicament destiné au traitement d'un trouble pour lequel l'administration d'un antagoniste sélectif de mGluR1 est indiquée.

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