Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

C

C07C 211/30 (2006.01) A61K 31/135 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/445 (2006.01) A61K 31/46 (2006.01) A61K 31/47 (2006.01) A61P 25/28 (2006.01) C07C 215/42 (2006.01) C07C 217/56 (2006.01) C07C 217/74 (2006.01) C07C 323/32 (2006.01) C07D 215/12 (2006.01) C07D 217/14 (2006.01) C07D 277/64 (2006.01) C07D 295/03 (2006.01) C07D 295/096 (2006.01) C07D 307/79 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/58 (2006.01)

Patent

CA 2419777

A compound of the formula in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholino group, said group being optionally substituted with 1 to 3 substituents selected from C1-4 alkyl, hydroxymethyl, C1-4 alkoxymethyl and amido, R3 is a naphthyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; and m is 0 or 1, provided that when m is 1 then n is 1; or a salt or ester thereof.

L'invention concerne un composé de la formule (I). R?1¿ et R?2¿ représentent chacun hydrogène ou C¿1-4? alkyle, ou R?1¿ et R?2¿ ainsi que l'atome d'azote auquel ils sont liés forment un groupe azétidinyle, pyrrolidinyle, pipéridinyle, pipérazinyle ou morpholino, ledit groupe étant éventuellement substitué par 1 à 3 substituants choisis dans C¿1-4? alkyle, hydroxyméthyle, C¿1-4? alkoxyméthyle et amido; R?3¿ représente un groupe naphthyle, indolyle, benzothiényle, benzofuranyle, benzothiazolyle, quinolinyle ou isoquinolinyle, ledit groupe étant éventuellement substitué; et n représente 1 ou 2, m représentant 0 ou 1, pour autant que lorsque m est égal à 1, n soit égal à 1; ou un sel ou ester de ces derniers.

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