Pharmaceutical compounds

Details Pharmaceutical compounds Pharmaceutical compounds

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4162 (2006.01)

Patent

CA 2507710

Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: (see formula I) wherein: A represents a group selected from one of the following: (CH2) t-, -(CH2) -S (O) z-, or -S (O) z-(CH2)-, - B is a heteroaryl, optionally substituted; - R is a group selected from the following: - alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; - R' is a group selected from the following: - an ether group of formula - (CH2) -O- (CH2) v-R", - a ketonic group of formula -C (O) -Z' , wherein Z' is as defined below; - a substituent having an hydroxyl function of formula -CH (OH) -Z'; - an amide substituent of formula -C(O)-NH-T'.

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