Pharmaceutical compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 491/052 (2006.01) A61K 31/47 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2103203

ABSTRACT Pharmaceutical compounds of the formula Image (I) R1 is phenyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl and heteroaryl groups being optionally substituted, or R1 is furanyl optionally substituted with C1-4 alkyl; R2 is nitrile, carboxy, -COOR4 where R4 is an ester group, -CONR5R6 where R5 and R6 are each hydrogen or C1-4 alkyl, or R7SO2- where R7 is C1-4 alkyl or optionally substituted phenyl; R3 is -NR8R9, -NHCOR8, -N(COR8)2, -N=CHOR8 where R8 and R9 are each hydrogen or C1-4 alkyl, or -NHSO2R10 where R10 is C1-4 alkyl or optionally substituted phenyl; or Image where X is C2-4 alkylene; and the group Image represents a pyridine ring fused to the benzopyran nucleus; and salts thereof.

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