C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 285/16 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2245331
A pharmaceutical compound having the formula: (see fig. I) in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3, R1 and R2 are each hydrogen or C1-4 alkyl, R3, R4 and R5 are each hydrogen, C1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R3 and R4 together form an alkylene link of formula -(CH2)3- or -(CH2)4-, or R4 and R5 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, R6 is C1-4 alkyl, C1-4 alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro or amino, the dotted line represents an optional double bond, and the fluorine atom is attached at the 6 or 7-position; and salts and esters thereof.
Composé pharmaceutique de formule (voir fig. I), dans laquelle n est 1 ou 2, m est 1 ou 2, p est 1 à 6, q est 0 ou 1 à 3; R1 et R2 sont chacun un hydrogène ou un alkyle C1-4; R3, R4 et R5 sont chacun un hydrogène, un alkyle C1-4, un phényle avec substitution facultative ou un phénylalkyle C1-4 avec substitution facultative; ou R3 et R4 forment ensemble un lien alkylène de formule -(CH2)3- ou -(CH2)4-; ou R4 et R5 forment ensemble avec l'atome de carbone auquel ils sont liés un groupe cycloalkyle C3-6; R6 est un groupe alkyle C1-4, alcoxy C1-4, carboxy, hydroxy, cyano, halo, trifluorométhyle, nitro ou amino; la ligne en pointillé représente une double liaison facultative, et l'atome de fluor est fixé en position 6 ou 7. L'invention porte aussi sur des sels et des esters de ce composé.
Eli Lilly And Company Limited
Gowling Lafleur Henderson Llp
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