Pharmaceutical compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/14 (2006.01) A61K 31/4155 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2507712

Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: (See formula I) wherein: - R is a group selected from: - C1-C10 alkyl; - aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; - A is a group selected from the following: - an ether group of formula -(CH2)-O-(CH2)v-R" wherein - v is equal to 1 or 2; - R" is as defined in the present application; - a ketone group of formula -C(O)-Z', wherein Z' is as defined in the present application; - a substituent having an hydroxyl function of formula -CH(OH)-Z', Z' being as defined in the present application; - an amide substituent of formula -C(O)-NH-T', T' being as defined in the present application; - B is a group as defined in the present application; - D is an heteroaryl optionally substituted.

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