C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 253/08 (2006.01) A61K 31/472 (2006.01) A61K 31/502 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 217/22 (2006.01) C07D 237/28 (2006.01) C07D 237/30 (2006.01)
Patent
CA 2593005
Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
L'invention concerne des 1-arylamino-phtalazines, des 4-arylamino-benzo[d][1,2,3]triazines et des analogues de ces composés présentant une efficacité comme activateurs de caspases et inducteurs d'apoptose. Les composés selon l'invention peuvent être utilisés pour traiter divers états cliniques caractérisés par une croissance et une propagation incontrôlées de cellules anormales.
Anderson Mark B.
Cai Sui Xiong
Halter Robert J.
Jiang Songchun
Klimova Yevgeniya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cytovia Inc.
Myriad Genetics Inc.
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