Pharmaceutical compounds, preparation, use and intermediates...

Details Pharmaceutical compounds, preparation, use and intermediates... Pharmaceutical compounds, preparation, use and intermediates...

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/06 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1248299

ABSTRACT Novel peptides of formula (I) X-Tyr-X2-Gly-Phe(4NO2)-Pro-NH2 (I) and salts thereof, wherein X is hydrogen or an amidino group and X2 is a radical selected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesic effect when administered to mammals. The compounds also exhibit antidiarrhoeal and antitussive activity and may thus be used in human or veterinary medicine for the relief or prevention of pain, for the treatment of diarrhoea or dysentery and for the suppression of cough.

420948

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