Pharmaceutical delivery system

Details Pharmaceutical delivery system Pharmaceutical delivery system

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61P 15/02 (2006.01) A61K 31/7056 (2006.01)

Patent

CA 2540129

A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 ~g to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL.hr.

L'invention porte sur une préparation pharmaceutique destinée à traiter les troubles vaginaux et comprenant: au moins un principe actif et une forme posologique modifiée provoquant une libération accrue de l'agent anti-infectieux après administration vaginale. Ladite préparation contient une dose totale d'un agent antiinfectieux comprise entre environ 25?g et environ 500 mg (de l'agent actif) qui produit une courbe de concentration plasmatique dans le temps (ng/ml par heure) dont la partie située sous la courbe (AUC) est inférieure à environ 600 ng/ml par heure.

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