Pharmaceutical device for the administration of substances...

Details Pharmaceutical device for the administration of substances... Pharmaceutical device for the administration of substances...

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2629894

Biological materials such as vaccines can be stabilised in certain glassy materials soluble in water. It has been proposed to form these glassy materials as a powder suspended in a non-aqueous liquid for injection into a patient. This method is complicated by the need to find suitable compatible liquids and to stop the glassy particles from congregating in liquid. These problems have been obviated by supporting the glassy material on a porous membrane remote from the eluant. When the biological material requires administration, the eluant can be passed across the membrane dissolving the glass and causing the substance to be carried by the liquid into the patient.

La présente invention concerne des matériaux biologiques, tels que des vaccins, pouvant être stabilisés dans certains matériaux vitreux solubles dans l~eau. Il a été proposé de constituer ces matériaux vitreux sous forme de poudre suspendue dans un liquide non aqueux, destiné à être injecté à un patient. Ce procédé est compliqué par la nécessité de trouver des liquides compatibles appropriés et d~empêcher les particules vitreuses de s~agréger dans le liquide. Il a été paré à ces problèmes en maintenant le matériau vitreux sur une membrane poreuse éloignée de l~éluant. Lorsque le matériau biologique doit être administré, l~éluant peut être passé à travers la membrane dissolvant le verre, ce qui induit le transport de la substance vers le patient par le biais du liquide.

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