Pharmaceutical dosage form comprising nifedipine or...

Details Pharmaceutical dosage form comprising nifedipine or... Pharmaceutical dosage form comprising nifedipine or...

A - Human Necessities

61

K

A61K 9/28 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4422 (2006.01)

Patent

CA 2744515

The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.

La présente invention porte sur une forme galénique pharmaceutique contenant une combinaison de principes actifs de nifédipine ou de nisoldipine et d'au moins un antagoniste de l'angiotensine II et/ou au moins un diurétique, caractérisée en ce que la nifédipine ou la nisoldipine sont libérées dans l'organisme d'une manière contrôlée (modifiée), et l'antagoniste de l'angiotensine II et/ou le diurétique sont rapidement libérés (libération immédiate, immediate release (IR)). L'invention porte également sur un procédé de préparation de cette forme galénique, sur son utilisation en tant que médicament, ainsi que son utilisation pour la prophylaxie, la prophylaxie secondaire ou le traitement de maladies.

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