Pharmaceutical dosage form for pulsatile delivery of...

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A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/54 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/4458 (2006.01) A61K 45/06 (2006.01) A61K 9/16 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2368367

Novel pharmaceutical dosage forms provide for pulsatile delivery of methylphenidate, i.e., release encapsulated drug in spaced apart "pulses". The dosage forms are comprised of first, second and optionally third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads or particles, or may comprise a single tablet with the first, second and optionally third dosage units each representing an integral and discrete segment thereof. Methods of treatment using the pharmaceutical dosage forms are provided as well.

L'invention concerne de nouvelles formes posologiques pharmaceutiques qui permettent l'administration intermittente de méthylphénidate, c'est-à-dire, qui libèrent le produit encapsulé par intermittence. Les formes posologiques selon l'invention se constituent de première, deuxième et éventuellement troisième unités posologiques, chaque unité présentant un profil de libération du médicament différent. Ces formes peuvent comprendre des capsules dans lesquelles sont placés des comprimés ou des perles ou des particules contenant le médicament, ou peuvent comprendre un seul comprimé renfermant les première, deuxième et éventuellement troisième unités posologiques représentant chacune un segment discret et solidaire de ces dernières. L'invention traite également de procédés de traitement utilisant les formes posologiques selon l'invention.

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