Pharmaceutical dosage forms comprising a lipid phase

Details Pharmaceutical dosage forms comprising a lipid phase Pharmaceutical dosage forms comprising a lipid phase

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 9/02 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2607738

A tablet for oral administration comprises a lipid phase, comprised to 80% by weight or more by a mixture of (a) triglyceride, (b) mono- or/and diglyceride, and (c) cell membrane lipid; (d) one or more pharmacologically active agents dissolved or dispersed in the lipid phase; (e) water and/or ethanol; and (f) an absorption controlling amount of particulate pharmaceutical excipient. Also disclosed are granules, a suppository for rectal administration, and a capsule filled with the granules . Methods for preparing the tablet, the suppositoriy and the granules are also disclosed as well as uses of the granules and a method for coating them.

Un comprimé pour administration orale comprend une phase lipidique, constituée de 80 % en poids ou plus d'un mélange de (a) un triglycéride, (b) un monoglycéride et/ou un diglycéride et (c) un lipide de membrane cellulaire ; (d) un ou plusieurs agents actifs du point de vue pharmacologique dissous ou dispersés dans la phase lipidique ; (e) de l'eau et/ou de l'éthanol ; et (f) une quantité régulant l'absorption d'un excipient pharmaceutique particulaire. Il est également exposé des granules, un suppositoire pour administration rectale et une gélule contenant les granules. Il est également exposé des procédés servant à préparer le comprimé, le suppositoire et les granules ainsi que des utilisations des granules et un procédé servant à les enrober.

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