Pharmaceutical excipient having improved compressibility

Details Pharmaceutical excipient having improved compressibility Pharmaceutical excipient having improved compressibility

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) B01J 2/00 (2006.01)

Patent

CA 2183881

A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1 % to about 20 % silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanomoter to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

Excipient à base de cellulose microcristalline et à compressibilité améliorée, utilisable en compression directe, en granulation par voie sèche ou en granulation par voie humide. Cet excipient est un agglomérat de particules de cellulose microcristalline et de 0.1 à 20 % en poids environ de particules de dioxyde de silicium, par rapport au poids de la cellulose microcristalline, la cellulose microcristalline et le dioxyde de silicium étant en association intime l'un avec l'autre. Les particules du dioxyde de silicium utilisé dans ce nouvel excipient ont une grosseur comprise entre environ 1 nanomètre et environ 100 microns. De préférence, le dioxyde de silicium est du dioxyde de silicium colloïdal de qualité donnée.

Affiliated with

Also associated with

Rating

Pharmaceutical excipient having improved compressibility does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical excipient having improved compressibility, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical excipient having improved compressibility will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1577295