A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 31/167 (2006.01) A61K 31/277 (2006.01) A61K 31/56 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2439366
The present invention relates to a pharmaceutical formulation comprising bicalutamide and an enteric polymer having a pKa from 3 to 6. The invention also relates to a daily pharmaceutical dose of bicalutamide provided by such a formulation. In addition, the invention relates to the use of such an enteric polymer in solid dispersion with bicalutamide for increasing the bioavailability of the bicalutamide; for reducing inter-patient variability in plasma concentrations of bicalutamide; or for treating and/or reducing the risk of prostate cancer in a patient.
L'invention concerne une préparation pharmaceutique comprenant du bicalutamide et un polymère entérique possédant un pK¿a? compris entre 3 et 6. Cette invention concerne également une dose pharmaceutique journalière fournie par une telle préparation. En outre, l'invention concerne l'utilisation d'un tel polymère entérique dans une dispersion solide avec du bicalutamide pour augmenter la biodisponibilité du bicalutamide, pour diminuer la variabilité d'un patient à l'autre des concentrations plasmatiques du bicalutamide, ou pour traiter et/ou réduire le risque de cancer de la prostate chez un patient.
Bateman Nicola
Cahill Julie
Astrazeneca Ab
Fetherstonhaugh & Co.
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