Pharmaceutical formulation comprising ezetimibe

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 31/397 (2006.01)

Patent

CA 2708159

The present invention relates to novel formulations comprising ezetimibe as active ingredient. In particular the invention relates to a pharmaceutical composition comprising 5 to 20 wt-% ezetimibe, 50 to 85 wt-% diluent, 3 to 25 wt-% disintegrant, 1 to 10 wt-% binder, and 0.5 to 1 wt-% lubricant, characterized in that the ezetimibe has a particle size distribution of d(0.9) of 5 µm to 35 µm and d(0.5) of 3 µm to 20 µm, as well as methods for preparing said formulations.

La présente invention concerne de nouvelles formulations comprenant de l'ézétimibe en tant qu'ingrédient actif. L'invention concerne notamment une composition pharmaceutique qui comprend 5 à 20 % en poids d'ézétimibe, 50 à 85 % en poids de diluant, 3 à 25 % en poids de délitant, 1 à 10 % en poids de liant et 0,5 à 1 % en poids de lubrifiant, caractérisée en ce que l'ézétimibe a une distribution de tailles de particule d(0,9) de 5 µm à 35 µm et d(0,5) de 3 µm à 20 µm. L'invention concerne également des procédés de préparation desdites formulations.

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