A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01)
Patent
CA 2531853
There is provided a stable pharmaceutical formulation comprising (a) an effective amount of levothyroxine sodium, (b) microcrystalline cellulose which has a mean particle size of less than 125~m and is present in an amount of 60 to 85% w/w based upon the total weight of the formulation, and (c) pregelatinised starch present in an amount of 5 to 30% w/w based upon total weight of the formulation. There is also provided a process for the preparation of such a formulation.
L'invention concerne une formulation pharmaceutique stable comprenant (a) une dose efficace de sodium de lévothyroxine, (b) de la cellulose microcristalline de dimension particulaire moyenne inférieure à 125 µm et présente en dose de 60 à 85 % en poids sur la base du poids total de la formulation, et (c) de l'amidon prégélatinisé présent en dose de 5 à 30 % en poids sur la base du poids total de ladite formulation. L'invention concerne enfin un procédé de préparation d'une telle formulation.
Konieczna Malgorzata
Krohn Heiner
Roman Wanda
Schlehahn Hendrik
Strozyk Malgorzata Anna
Aspen Global Incorporated
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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