C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/88 (2006.01) A61K 38/51 (2006.01) A61P 7/02 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2318356
The invention relates to pharmaceutical compositions which are especially suitable as injection preparations to be used for the therapy of vascular diseases which are caused by atheromatous deposits on the inner walls of arteria. Said injection preparations contain bacterial hyaluronate lyase or a hyaluronate-digesting enzyme fragment produced from said enzyme. The invention also relates to the hyaluronate-digesting enzyme fragment of the bacterial hyaluronate lyase. It may be produced by treating the holoenzyme with a specifically digesting protease.
L'invention concerne des formulations pharmaceutiques particulièrement adaptées comme préparations d'injection ayant une application thérapeutique dans le cas des maladies vasculaires apparaissant à la suite de dépôts athéromateux sur les parois internes des artères. Ces préparations d'injection contiennent une lyase d'hyaluronate d'origine bactérienne ou un fragment enzymatique dissociant l'hyaluronate et produit à partir de cet enzyme. L'invention concerne également le fragment enzymatique dissociant l'hyaluronate de la lyase d'hyaluronate bactérienne. On peut l'obtenir par traitement de l'holoenzyme avec une protéase spécifique.
Hartl Albert
Muller Peter-Jurgen
Ozegowski Jorg-Hermann
Peschel Gundela
Presselt Norbert
Id Pharma Gmbh
Na
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