Pharmaceutical formulation containing an ltb4 antagonist,...

A - Human Necessities – 61 – K

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A61K 31/27 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2544049

The invention relates to a novel pharmaceutical formulation containing an LTB4 antagonist of formula (I), wherein A, R1, R2, R3, and R4 have the meaning indicated in claim 1, the pharmacologically acceptable acid addition salt thereof, glycoside, O-sulfate, or glucuronide as an active substance, and at least one optional pharmacologically acceptable auxiliary agent and/or carrier, the active substance being provided as a solid solution or solid dispersion in a polymer matrix. The invention also relates to the production thereof, the use thereof as a medicament, and said solid solutions and dispersions.

L'invention concerne une nouvelle formulation de médicament contenant un antagoniste de LTB¿4? de formule (I) dans laquelle A, R¿1?, R¿2?, R¿3? et R¿4? sont tels que définis dans la première revendication, ou un sel d'addition acide pharmacologiquement acceptable, glycoside, O-sulfate ou glucoronide de cet antagoniste, en tant que principe actif, et comprenant en outre éventuellement au moins un adjuvant et/ou support pharmacologiquement acceptable. Selon l'invention, le principe actif se présente sous la forme d'une solution solide ou dispersion solide dans une matrice polymère. Cette invention se rapporte également à la production de cette formulation, et à son utilisation en tant que médicament, ainsi qu'auxdites solutions et dispersions solides.

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