Pharmaceutical formulation containing tolterodine and its use

Details Pharmaceutical formulation containing tolterodine and its use Pharmaceutical formulation containing tolterodine and its use

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) A61K 31/137 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2387973

The invention relates to a pharmaceutical formulation containing tolterodine or a tolterodine-related compound, or a pharmacologically acceptable salt thereof, as active ingredient, in which the formulation exhibits a controlled in vitro release of the active ingredient in phosphate buffer at pH 6.8 of not less than about 80 % after 18 hours, and after oral administration to a patient is capable of maintaining a substantially constant serum level of the active moiety or moieties for 24 hours. The invention also relates to the use of the pharmaceutical formulation for treating overactive bladder and gastrointestinal disorders.

L'invention concerne une formulation pharmaceutique contenant, comme principe actif, de la toltérodine, un composé lié à la toltérodine ou un de leurs sels pharmaceutiquement compatibles. La formulation présente une libération in vitro contrôlée du principe actif dans un tampon de phosphate de pH 6.8 d'environ 80 % minimum au bout de 18 heures. Après administration par voie orale à un patient, cette formulation est capable de maintenir un niveau de sérum sensiblement constant du ou des groupe(s) caractéristiques actif(s) pendant 24 heures. L'invention concerne également l'utilisation de cette formulation pharmaceutique pour traiter un vessie suractive et des troubles gastro-intestinaux.

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