Pharmaceutical formulation for aerosols, comprising two or...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 31/137 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2641883

The invention relates to novel pharmaceutical formulations for aerosols, comprising at least two or more active agents and at least one surfactant and suitable for inhalative or nasal application. The invention particularly relates to pharmaceutical preparations for propellant-containing dosage aerosols containing a fluorohydrocarbon (HFA) as propellant, said preparations containing an active agent combination of at least two or more active agents, wherein at least one active agent is present in dissolved form and at least another active agent is present in the form of suspended particles in conjunction with at least one surfactant.

L'invention concerne de nouvelles formulations pharmaceutiques destinées à des aérosols, contenant au moins deux agents actifs et au moins une substance tensioactive, lesdites formulations étant destinées à une application nasale ou par inhalation. L'invention concerne plus particulièrement des préparations pharmaceutiques destinées à des aérosols de dosage à gaz propulseur, contenant un hydrocarbure fluoré (HFA) en tant que gaz propulseur, une combinaison d'agents actifs composée d'au moins deux agents actifs dont au moins un agent actif est présent sous forme dissoute et au moins un autre agent actif est présent sous forme de particules en suspension, ainsi qu'une substance tensioactive.

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