Pharmaceutical formulation for delivery of receptor tyrosine...

Details Pharmaceutical formulation for delivery of receptor tyrosine... Pharmaceutical formulation for delivery of receptor tyrosine...

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 9/10 (2006.01) A61K 31/416 (2006.01)

Patent

CA 2693888

The present invention relates to development of efficacious pharmaceutical ophthalmic compositions comprising a poorly water soluble active compound in a therapeutically effective amount and a polyethylene co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability. The composition is in the form of a gel, and the prefered active compound is the multi-targeted receptor tyrosine kinase' inhibitor N-[4-(3-amino-1H-indazol-4-yl) phenye]-N-(2-fluoro-5-methylphenye)urla].

La présente invention concerne le développement de compositions pharmaceutiques efficaces comportant un composé actif peu hydrosoluble en une quantité thérapeutiquement efficace et un cosolvant en une quantité appropriée pour traiter ou prévenir des maladies dues à la néovascularisation oculaire et la perméabilité vasculaire activée. Dans des aspects préférés, la composition est sous la forme d'un gel.

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