Pharmaceutical formulation for the intramuscular...

Details Pharmaceutical formulation for the intramuscular... Pharmaceutical formulation for the intramuscular...

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 31/565 (2006.01) A61K 47/10 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2453111

The invention relates to a sustained release pharmaceutical formulation adapted for administration by injection containing the compound fulvestrant, 7 a-[9-(4,4,5,5,5-pentafluoropentylsulphiny1)nony1]oestra-1,3,5(10)-triene-3,17 .szlig.-diol, at concentration of at least 100mg/ml in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.

La présente invention concerne une formulation pharmaceutique à libération prolongée, adaptée à l'administration par injection, contenant le composé de fulvestrant, 7 a-[9-(4,4,5,5,5-pentafluoropentylsulphiny1)nony1]oestra-1,3,5(10)-triène-3,17 .szlig.-diol, à une concentration d'au moins 100mg/ml en solution dans un excipient de ricinoléate qui comprend également au moins un alcool et un solvant ester non aqueux miscible dans l'excipient de ricinoléate.

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