A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/706 (2006.01) A61K 47/40 (2006.01) A61P 7/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2589052
The present invention provides pharmaceutical formulations of decitabine or 5- aza-2~-deoxycytidine as well as methods of manufacturing the formulations. In particular, decitabine is formulated with a cyclodextrin compound to stabilize and/or enhance solubility of the drug. Kits and methods for using the pharmaceutical formulations are also provided, including methods of administering decitabine to treat conditions or diseases, such as cancer and hematological disorders.
L'invention concerne des formulations pharmaceutiques de décitabine ou de 5-aza-2'-désoxycytidine, ainsi que des procédés de préparation de ces formulations. Ces formulations de décitabine comprennent notamment un composé de cyclodextrine permettant de stabiliser et/ou d'augmenter la solubilité du médicament. L'invention concerne également des trousses et des méthodes d'utilisation de ces formulations pharmaceutiques, notamment des méthodes d'administration de décitabine pour le traitement d'affections ou de maladies telles que le cancer et les troubles hématologiques.
Joshi-Hangal Rajashree
Tang Chunlin
Borden Ladner Gervais Llp
Supergen Inc.
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