Pharmaceutical formulation of nitrooxyderivatives of nsaids

Details Pharmaceutical formulation of nitrooxyderivatives of nsaids Pharmaceutical formulation of nitrooxyderivatives of nsaids

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 31/216 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2616508

The present invention relates to a pharmaceutical formulation comprising: a) one or more NO-releasing NSAID(s) of formula (I); b) one or more surfactants; c) a carbonyl scavenger compound selected from free acid forms, salts, carboxylic acid esters derivatives of a compound of formula (II): H2N-(CH2)m- (C6H4)-COOH wherein m = 0-10; and d) optionally an oil or semi-solid fat and/ or a short-chain alcohol.

La présente invention concerne une préparation pharmaceutique comprenant : a) un ou plusieurs AINS libérant du NO représentés par la formule (I) ; b) un ou plusieurs tensioactifs ; c) un composé accepteur carbonyle sélectionné parmi des formes d'acides libres, des sels, des dérivés d'esters d'acide carboxylique d'un composé représenté par la formule (II) : H2N-(CH2)m-(C6H4)-COOH, dans laquelle m = 0-10 ; et d) éventuellement une huile ou une graisse semi-solide et/ou un alcool à chaîne courte.

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