A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2232715
The invention provides a controlled-release pharmaceutical formulation for oral administration consisting essentially of: an active drug compound; low molecular weight polyethylene oxide; hydroxypropylmethyl cellulose; tabletting excipients; and optionally one or more enteric polymers. Formulations according to the invention produce a constant rate of release of drug in in vitro models of the gastrointestinal tract.
L'invention concerne une formulation pharmaceutique à libération prolongée, destinée à une administration par voie orale et comprenant essentiellement un composé médicamenteux actif, un oxyde de polyéthylène à bas poids moléculaire, une cellulose d'hydroxypropylméthyle, des excipients de fabrication de comprimés, et éventuellement un ou plusieurs polymères entérosolubles. Avec des formulations selon l'invention, on obtient un taux constant de libération de médicament dans des modèles in vitro du tractus gastro-intestinal.
Macrae Ross James
Smith Janet Sarah
Pfizer Research And Development Company N.v./s.a.
Smart & Biggar
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