A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/11 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 47/42 (2006.01)
Patent
CA 2484724
Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form which provides for a rapid dispersion of the active substance in the oral cavity. Thereby, desmopressin may be absorbed across the sublingual, buccal and/or gingival mucosa, and/or from the gastrointestinal tract for systemic distribution. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water- soluble or water-dispersible carrier material. Desmopressin formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary nocturnal enuresis (PNE), nocturia or central diabetes insipidus. A process for the production of the dosage form by subliming solvent from a composition comprising desmopressin and a solution of carrier material is also provided.
On peut obtenir de la desmopressine présentant une bonne biodisponibilité au moyen d'une forme posologique pouvant se disperser dans la bouche. Les formes posologiques préférées comportent de la desmopressine et un réseau matriciel ouvert du type support hydrosoluble inerte ou pouvant se disperser dans l'eau. La desmopressine ainsi formulée peut servir à retarder la miction ou à traiter ou prévenir l'incontinence, l'énurésie nocturne primaire, la nycturie ou le diabète insipide d'origine centrale. On peut également formuler de cette manière des peptides autres que la desmopressine.
Lindner Hans
Nilsson Anders
Wittendorff Jorgen
Ferring B.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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