Pharmaceutical formulations and methods of use which combine...

Details Pharmaceutical formulations and methods of use which combine... Pharmaceutical formulations and methods of use which combine...

A - Human Necessities

61

K

A61K 31/405 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2726337

An oral dosage form of a non-steroidal anti-inflammatory drug (NSAID) is rendered safer for extended or chronic use for anti-inflammatory, analgesic or antipyretic therapy by combining it with an antihypertensive drug. The antihypertensive drug acts prophylactically to inhibit or reduce NSAID-induced hypertension and by so doing the adverse cardiovascular side effects of NSAIDs, such as high blood pressure, heart attack, stroke, opththamologic complications, and death, when NSAIDs are used repetitively over an extended period of time for reducing inflammation or in pain management.

On rend une forme pharmaceutique orale de médicament antiinflammatoire non stéroïde plus sûre pour une utilisation étendue ou chronique en thérapie antiinflammatoire, analgésique ou antipyrétique en la combinant avec un médicament hypertensif, lequel agit de façon prophylactique pour inhiber ou pour réduire l'hypertension induite par ce médicament, et du même coup inhiber ou réduire les effets secondaires néfastes d'un tel médicament sur le plan cardio-vasculaire, qui peuvent engendrer l'hypertension artérielle, l'infarctus, l'AVC, des complications ophtalmologiques et la mort, en cas d'utilisation répétitive dudit médicament sur une longue durée pour réduire l'inflammation ou gérer la douleur

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