A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4745 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61K 47/44 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/12 (2006.01)
Patent
CA 2467828
Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2- bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo- quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.
L'invention concerne des formulations pharmaceutiques comprenant un modificateur de réponse immunitaire (IRM) choisi parmi les imidazoquinoline amines, les imidazotétrahydroquinoline amines, les imidazopyridine amines, les cycloalkylimidazopyridine amines 6,7-condensées, les imidazoquinoline amines 1,2-pontées, les thiazolo-quinolineamines, les oxazolo-quinolinamines, les thiazolo-pyridinamines, les oxazolo-pyridinamines, les imidazonaphthyridine amines, les tétrahydroimidazonaphthyridine amines, et les thiazolonaphthyridine amines. Ces formulations pharmaceutiques comprennent également un acide gras et un composant hydrophobe aprotique miscible avec l'acide gras utile dans le traitement de pathologies associées au derme. L'invention fournit de nouvelles formulations topiques. Dans l'un des modes de réalisation, les formulations topiques sont avantageuses dans le traitement de la kératose actinique, de cicatrices post-chirurgicales, du carcinome baso-cellulaire, de la dermatite atopique, et des verrues.
Busch Terri F.
Fretland Mary T.
Gust-Heiting Amy L.
Scholz Matthew T.
Skwierczynski Raymond D.
3m Innovative Properties Company
Robic
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