Pharmaceutical formulations comprising dextran with...

A - Human Necessities – 61 – K

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A61K 47/36 (2006.01) A61K 9/52 (2006.01) A61L 27/20 (2006.01) A61L 31/06 (2006.01)

Patent

CA 2636173

A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0 - 100 kDa and introducing the liquid composition into the body of a mammal, whereby the implant is formed in situ in the body of the mammal. A process for preparing a composition useful for biomedical application, comprising the steps of providing a liquid composition comprising an aqueous solution of dextran having a molecular weight of 1 - 100 kDa; andbringing the liquid composition to solidify; whereby water is gradually eliminated from the liquid composition during the soldification. A biomedical article prepared from the composition.

L~invention concerne un implant solide ou semi-solide obtenu à partir d~une composition liquide comprenant une solution aqueuse de dextrane ayant un poids moléculaire de 1,0 à 100 kDa, ladite composition liquide étant introduite dans le corps d~un mammifère et l~implant étant formé in situ dans le corps du mammifère. L~invention concerne également un procédé visant à préparer une composition utile dans le cadre d~applications biomédicales, ledit procédé comprenant les étapes consistant à fournir une composition liquide comprenant une solution aqueuse de dextrane ayant un poids moléculaire de 1 à 100 kDa, puis à solidifier ladite composition liquide, l~eau étant progressivement éliminée de la composition liquide pendant la solidification. L~invention concerne en outre un article biomédical préparé à partir de ladite composition.

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