Pharmaceutical formulations containing poorly soluble drug...

A - Human Necessities – 61 – K

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A61K 31/19 (2006.01) A61K 9/20 (2006.01) A61K 31/00 (2006.01) A61K 31/192 (2006.01) A61K 31/44 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2281946

Pharmaceuticals formulations of poorly soluble drug substances in the form of: concentrated solutions for filling soft gelatin capsules; solid dispersions and suspensions for filling hard gelatin capsules are provided. The solvent system used includes xylitol, dicalcium phosphate dihydrate, lactose monohydrate, microcrystalline cellulose, propylene glycol and NaOH.

L'invention porte sur des préparations pharmaceutiques de substances médicamenteuses faiblement solubles sous forme de solutions concentrées destinées au remplissage de gellules de gélatine molle, et de dispersions et suspensions de solides destinées au remplissage de gellules de gélatine dure. Le système de solvants utilisé comprend du xylitol, du dicalcium, du dihydrate de phosphate, du monohydrate de lactose, de la cellulose microcristalline, du propylène glycol et de la NaOH.

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