Pharmaceutical formulations of aliphatic amine polymers and...

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01)

Patent

CA 2642255

The present invention provides pharmaceutical compositions comprising aliphatic amine polymers such as for example Sevelamer HCl as the active pharmaceutical ingredient, wherein the aliphatica amine polymers are spray granulated. The present invention further provides methods of preparing stable pharmaceutical compositions of aliphatic amine polymers such as for example Sevelamer HCl, preferably in tablets dosage forms.

La présente invention concerne des compositions pharmaceutiques comprenant des polymères d'amines aliphatiques, comme par exemple le Sevelamer HCl au titre de principe actif pharmaceutique, lesdits polymères d'amines aliphatiques étant granulés par atomisation. La présente invention concerne en outre des méthodes d'élaboration de compositions pharmaceutiques stables de polymères d'amines aliphatiques, comme par exemple Sevelamer HCl, préférentiellement sous forme de comprimés.

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