Pharmaceutical formulations of ciprofloxacin

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1296634

ABSTRACT A pharmaceutical formulation comprising by weight 30 to 95% of 1-cyclopropyl-6-fluoro-1,4-dihydro- 4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid; 4.5 to 25% of a dry binder based on cellulose; 0 to 30% of a disintegration auxiliary based on starch; 0.5 to 10% of a disintegration auxiliary based on a cellulose derivative and/or a cross-linked polyvinyl-pyrrolidone; 0 to 2 % of a flow- improving agent, and 0 to 3% of a lubricant. Tablets and capsules made from granules of the formulation, about 0.8 to 2 mm in size, exhibit high bioavailability and excellent storage stability.

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