Pharmaceutical formulations of ghrh molecules

Details Pharmaceutical formulations of ghrh molecules Pharmaceutical formulations of ghrh molecules

A - Human Necessities

61

K

A61K 38/25 (2006.01) A61K 9/08 (2006.01) A61K 9/19 (2006.01)

Patent

CA 2680329

Stabilized solid and liquid pharmaceutical formulations comprising a GHRH molecules as active ingredient, and more particularly GHRH analogs including [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises an anionic surfactant and a non-reducing sugar, and has a pH of about 4.0 to about 7.5. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it.

Formulations pharmaceutiques solides et liquides stabilisées comprenant des molécules GHRH et plus particulièrement des analogues GHRH renfermant un [trans-3-hexènoyl]hGHRH (1-44) amide. Ce type de formulation comprend un tensio-actif anionique et un sucre non réducteur, avec un pH compris entre environ 4 et environ 7,5. On décrit aussi l'utilisation d'une telle formulation pour le traitement de diverses affections, des procédés d'élaboration de la formulation et des kits la contenant.

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