Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides

Details Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2750559

The present invention relates to a complex comprising a TGF-.beta.1 inhibitor peptide and a cyclodextrin or a derivative thereof. A TGF-.beta.1 inhibitor peptide emulsion comprising cetyl PEG/PPG-10/1 dimethicone is also provided. Processes for the preparation of said complex and said TGF-.beta.1 inhibitor peptide emulsion are also described, as well as its use for the manufacture of a medicament for the treatment of a disease or condition mediated by a TGF-.beta.1.

La présente invention concerne un complexe qui comprend un peptide inhibiteur de TGF-ß1 et une cyclodextrine ou un dérivé de cette dernière. L'invention concerne également une émulsion d'un peptide inhibiteur de TGF-ß1 qui comprend de la cétyl PEG/PPG-10/1 diméthicone. L'invention concerne en outre des procédés pour la préparation dudit complexe et de ladite émulsion, ainsi que leur utilisation pour la fabrication d'un médicament destiné au traitement d'une maladie ou d'un état pathologique médié par TGF-ß1.

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