Pharmaceutical formulations of xanthogenates and inhibitors...

A - Human Necessities – 61 – K

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A61K 31/265 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2539449

The invention relates to pharmaceutical formulations of xanthogenates and agents containing said formulations for use in the treatment of viral, cancer or autoimmune diseases. The pharmaceutical formulations contain a xanthogenate of formula (I), wherein R1 represents an optionally substituted aryl or alkyl group and R2 represents a metal atom, an optionally substituted alkyl, alkoxy, amino or ammonium group or halogen, and an inhibitor of viral nucleic acid replication such as e.g. aciclovir, valaciclovir, penciclovir, famciclovir, and optionally an excipient which reduces the irritating effects of xanthogenate and optionally an activity-increasing adjuvant.

L'invention concerne des formulations pharmaceutiques de xanthogénates et des agents contenant ces formulations, pour le traitement de maladies virales, tumorales ou auto-immunes. Lesdites formulations pharmaceutiques contiennent un xanthogénate correspondant à la formule (I), dans laquelle R¿1? représente un reste aryle ou alkyle éventuellement substitué et R¿2? représente un atome métallique, un groupe alkyle, alcoxy, amino ou ammonium éventuellement substitué, ou halogène, et un inhibiteur de la réplication virale d'acides nucléiques, tel que l'aciclovir, la valaciclovir, le penciclovir, le famciclovir, ainsi qu'éventuellement un support réduisant l'effet irritant du xanthogénate et, éventuellement, un adjuvant augmentant l'activité de la formulation.

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