Pharmaceutical formulations useful for inhibiting acid...

A - Human Necessities – 61 – K

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A61K 31/4439 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2609627

The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.

La présente invention concerne des préparations pharmaceutiques comprenant au moins un agent inhibant pour pompe à protons labile en milieu acide et au moins un anti-acide, qui marquent un progrès en matière de biodisponibilité, de stabilité chimique, de profils de dissolution, de durées de désintégration, d'innocuité et qui possèdent des propriétés pharmaco-cinétiques, pharmacodynamiques, chimiques et/ou physiques améliorées. L'invention porte sur de méthodes, des kits, des combinaisons et des compositions pour le traitement, la prévention et l'atténuation des risques que court un patient de contracter des troubles ou des maladies de l'appareil gastro-intestinal, ainsi que sur les symptômes associés ou en rapport avec ces troubles et maladies.

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