Pharmaceutical formulations useful for inhibiting acid...

A - Human Necessities – 61 – K

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A61K 47/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2566655

The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.

La présente invention concerne des formulations pharmaceutiques comprenant au moins un agent inhibant la pompe à protons labile en milieu acide et au moins un antiacide, qui possède une biodisponibilité, une stabilité chimique, une stabilité physique, des profils de dissolution, des durées de désintégration et un degré de sécurité améliorés, ainsi que d'autres propriétés pharmacocinétiques, pharmacodynamiques, chimiques et/ou physiques améliorées. La présente invention concerne des procédés, des kits, des combinaisons et des compositions, destinés au traitement, à la prévention ou à la réduction des risques de développement d'une maladie ou d'un trouble gastro-intestinal, ou des symptômes associés ou liés à une maladie ou à un trouble gastro-intestinal chez un sujet qui nécessite un tel traitement.

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