Pharmaceutical gallium compositions and methods

Details Pharmaceutical gallium compositions and methods Pharmaceutical gallium compositions and methods

A - Human Necessities

61

K

A61K 31/28 (2006.01)

Patent

CA 2626029

Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailability relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormally increased calcium resorption is desired, including cancer, hypercalcemia, osteoporosis, osteopenia and Paget's disease. Methods for preparation and treatment are also provided.

La présente invention concerne de nouvelles compositions pharmaceutiques de gallium comprenant des complexes gallium possédant une biodisponibilité par voie orale améliorée par rapport à des sels de gallium non complexés. Ces compositions conviennent pour le traitement d'états et de maladies dans lesquels l'inhibition de la résorption de calcium accrue de manière anormale est recherchée, notamment le cancer, l'hypercalcémie, l'ostéoporose, l'ostéopénie et la maladie de Paget. Cette invention concerne aussi des procédés de préparation et de traitement.

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