Pharmaceutical hydrogel formulations, drug delivery devices...

Details Pharmaceutical hydrogel formulations, drug delivery devices... Pharmaceutical hydrogel formulations, drug delivery devices...

A - Human Necessities

61

K

A61K 47/32 (2006.01) A61K 9/00 (2006.01) A61P 3/10 (2006.01) A61P 25/06 (2006.01) A61P 29/00 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2313642

Pharmaceutical hydrogel formulations containing polyvinyl alcohol are provided. The formulations may serve as drug reservoirs in electrotransport drug delivery systems (10) or passive transdermal systems, or they may be used in a variety of other types of dosage forms, e.g., capsules, suppositories, aerosols, and the like. With these formulations, there is virtually no syneresis encountered upon long term storage, an advantage that derives from selecting the quantity of polyvinyl alcohol in the gel to correspond to the polymer's degree of hydrolysis.

L'invention concerne des formulations pharmaceutiques à base d'hydrogel renfermant de l'alcool polyvinylique, qui peuvent servir de réservoirs à médicaments dans les systèmes d'administration des médicaments par électrotransport (10) ou dans les systèmes transdermiques passifs. On peut aussi utiliser ces formulations dans une série d'autres types de formes posologiques (par exemple, capsules, suppositoires, aérosols et autres). Lesdites formulations n'occasionnent pratiquement pas de synérèse en cas de stockage à long terme, un avantage venant du fait que l'on détermine la quantité d'alcool polyvinylique contenue dans le gel pour qu'elle corresponde au degré d'hydrolyse du polymère.

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